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Formulation design and pharmaceutical development of a

Formulation design and pharmaceutical development of a

Results: Azithromycin microspheres are small (approximately 200 microm) with a narrow particle size distribution. Drug release was optimized by controlling the amount of dissolution enhancer in the microspheres and by the addition of proper amount of alkalizing agents in the vehicle blend.

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Preparation of Polypropylene Powder by Dissolution

Preparation of Polypropylene Powder by Dissolution

Jul 14, 2019 Polypropylene (PP) powder with spherical morphology and suitable particle size for selective laser sintering (SLS) was successfully produced by dissolution-precipitation method. The influence of preparation condition on properties of PP powder was investigated. The experimental results show that the optimal preparation conditions are as follows: dissolution temperature being about …

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Advantages And Disadvantages In Particle Size Reduction

Advantages And Disadvantages In Particle Size Reduction

Jul 31, 2019 July 31,2019. Advantages and Disadvantages Of Different Particle Sizing Methods. Buy Together air jet sieve rotary sample divider particle size analyzer manufacturers fisher sub sieve sizer particle size analyzer price tap density tester Know More About. fisher particle sizing method air jet sieving particle sizing method laser diffraction particle sizing method.

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How Particle Size and Shape Influence Dissolution of

How Particle Size and Shape Influence Dissolution of

Particle size and shape strongly influences the dissolution behavior of multiparticulates used in pharmaceuticals, nutraceuticals, cosmetics, food -- any application where controlled release is desired. In this presentation, Kiwan Park of the HORIBA Applications Lab provides case studies where the CAMSIZER Dynamic Image Analyzer is being used to model and predict behavior of multiparticulate ...

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Particle size and fat encapsulation define the colloidal

Particle size and fat encapsulation define the colloidal

1. Introduction. Milk powder obtained by spray-drying results in different morphology and size, including spherical fines and agglomerates [].Large particles and agglomerates typically have a mean diameter in the range of 200–500 μm but can reach up to 1 mm in size [2,3].Fines or small particles are associated to diameters 125 μm [].Importantly, agglomerates have been observed to improve ...

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Mastersizer 3000 World's Leading Particle Size Analyzer

Mastersizer 3000 World's Leading Particle Size Analyzer

Particle size and particle size distribution analysis are critical to understanding the flow properties of a powder, since these characteristics help predict how particles within the powder will pack and lock together. Powders that have a large particle size with a narrow size …

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Particle Size and Shape Analysis using Imagej with

Particle Size and Shape Analysis using Imagej with

Fig. 3 Flow diagram of particle dimensions measurement and plugin algorithm. using modified approach Image analysis is one of the best methods for measuring powder size distribution. ImageJ software, which is freeware Java based Image Processing software, has been used in this paper for particle size distribution analysis. Other

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Effect of particle size distribution and flow property of

Effect of particle size distribution and flow property of

Control of particle size and size distribution is important because they influence the flowability (Fan et al., 2005; Li, 2008; Deanne and Etzler, 2009), tablettability (Sun and Himmelspach, 2006 ...

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Use of Spray Flash Evaporation SFE technology to improve

Use of Spray Flash Evaporation SFE technology to improve

Nov 15, 2020 The aspect and size of particles were studied through SEM analysis. The raw powder of furosemide was rod shaped with a quite large polydispersity (Fig. 3A).On the other hand, the SFE processed powder showed homogeneous spherical particles (Fig. 3B), with a much lower size than raw particles.The measured mean diameter of SFE particles was 396 nm (+/− 275 nm), whereas initial …

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Inhaled Dry Powder Formulation of Tamibarotene a Broad

Inhaled Dry Powder Formulation of Tamibarotene a Broad

Jun 10, 2021 The particle size, morphology, and the aerosol properties of SFD particles can be controlled by manipulating the operation parameters such as atomizing gas flow rate and drying temperature. [ 19 ] The current study aimed to develop SFD powder formulation of tamibarotene that can be used as an inhalable broad-spectrum antiviral therapy against ...

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Particle Size Reduction Equipment and Systems Bepex

Particle Size Reduction Equipment and Systems Bepex

PARTICLE SIZE REDUCTION. Particle size reduction and control often proves itself as a critical step in industrial solids processing systems. Often times it is used as a method for enacting positive results downstream, such as increasing surface area for efficient thermal treatment or milling and homogenizing a material for consistent mixing.

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Pharmaceuticals Particle Characterization Microtrac.com

Pharmaceuticals Particle Characterization Microtrac.com

With the introduction of Dynamic Image Analysis (DIA) as an alternative method, it is now possible to measure particle size and shape of powders, granulates, pellets and suspensions of particles 1 μm. A number of trials clearly demonstrate the advantages of DIA compared to the traditional particle …

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Effect of particle size on oral absorption of carvedilol

Effect of particle size on oral absorption of carvedilol

Effect of particle size on oral absorption of carvedilol nanosuspensions: in vitro and in vivo evaluation Dandan Liu,1 Hao Pan,2 Fengwei He,1 Xiaoyu Wang,3 Jinyu Li,3 Xinggang Yang,3 Weisan Pan31Department of Pharmaceutical Engineering, School of Biomedical and Chemical Engineering, Liaoning Institute of Science and Technology, Benxi, People’s Republic of China; 2School of …

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Pharmaceutical particle technologies An approach to

Pharmaceutical particle technologies An approach to

Dec 01, 2014 Pharmaceutical particle technology is employed to improve poor aqueous solubility of drug compounds that limits in vivo bioavailability owing to their low dissolution rate in the gastrointestinal fluids following oral administration. The particle technology involves several approaches from the conventional size reduction processes to the newer, novel particle technologies that modify the ...

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Effect of Particle Size on Detergent Powders Flowability

Effect of Particle Size on Detergent Powders Flowability

of powder particle size on flowability and tensile strength of formed ... However, the influence of particle size on the detergent powder activity and dissolution of compacted tablet are outside the scope of this study. Journal of Chemical Engineering & Process Technology. J o u r n a l o f C h e m i c a l E n g in er n g & P r o c e s s T e c ...

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Influence of particle size on the crystallization kinetics

Influence of particle size on the crystallization kinetics

Feb 01, 2013 In order to monitor bulk powder crystallization kinetics, Raman spectroscopy and PXRD measurements were performed on initially amorphous powder samples of two different particle sizes, following storage at different periods of time at 30 C.Raman and PXRD data obtained from the size 1 particle size fraction of pure felodipine are shown in Fig. 1, Fig. 2 respectively and confirmed the ...

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Physicochemical and flow properties of fruit powder and

Physicochemical and flow properties of fruit powder and

Nov 01, 2016 Additionally the powder particle size distribution and particle morphology, such as size and shape, had a significant effect on the flow properties, compressibility and dissolution rate. The addition of effervescent agent in the tablet formulation decreased flowability slightly, eventually it helps to reduce the dissolution time for fruit powder tablet significantly.

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Effect of particle size on the dissolution behaviors of

Effect of particle size on the dissolution behaviors of

Aug 03, 2012 This study examined the effects of the particle size of various poorly water-soluble drugs on their dissolution behavior through physicochemical and mathematical analysis. As model drugs, hydrochlorothiazide, aceclofenac, ibuprofen and a discovery candidate were selected. The materials were crystallized using an evaporation method and milled without transformation behavior of crystal forms ...

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Dissolution rate enhancement of loratadine in

Dissolution rate enhancement of loratadine in

Feb 01, 2013 The particle morphology was examined by SEM topographic mode with a secondary electron detector (Zeiss EVO 50). Samples were directly dispersed on a double-sided tape and made conductive by coating with gold. 2.8. Particle size distribution by light scattering

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PDF Powder Technology and Pharmaceutical Development

PDF Powder Technology and Pharmaceutical Development

te chnologies, improvements powder sampling procedures and measurements of particle surface. proper ties will be required. It is hoped that this paper will stimulate thought on this issue ...

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Effect of particle size on solubility dissolution rate

Effect of particle size on solubility dissolution rate

Nov 12, 2012 Taking dissolution medium B as an example, 1 mL of the coenzyme Q 10 nanocrystal suspensions of different particle size (drug content equals approximately 1 mg) was added to 2 mL of medium (containing 1.95% w/v Tween 20 and 7.5% v/v isopropanol) in a capped vial to give dissolution medium B (containing 1.3% w/v Tween 20 and 5.0% v/v isopropanol ...

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A basic guide to particle characterization

A basic guide to particle characterization

size. Particle size measurement is routinely carried out across a wide range of industries and is often a critical parameter in the manufacture of many products. Particle size has a direct influence on material properties such as: • reactivity or dissolution rate e.g. catalysts, tablets • stability in suspension e.g. sediments, paints

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Solving Powder Challenges Using Particle Size and Shape

Solving Powder Challenges Using Particle Size and Shape

Measuring the particle size and shape of powders is a common requirement for the development and quality control of countless products. This webinar explores the challenges associated with powder measurement including sampling, data interpretation, data quality, and verification. Laser diffraction is a well-known sizing technology suitable for ...

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The Role of Particle Size Analysis in the Development

The Role of Particle Size Analysis in the Development

Oct 01, 2010 Jinno, J., et al., Effect of particle size reduction on dissolution and oral absorption of a poorly water-soluble drug, cilostazol, in beagle dogs. J Control Release, 2006. 111(1-2): p. 56-64. 3.

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Resvantage The Resveratrol Supplement from Advantage

Resvantage The Resveratrol Supplement from Advantage

When particle size is reduced, the surface area of the compound is increased dramatically improving dissolution and absorption in the body. Tablets and powder filled capsules are inefficient and low in bioavailability because their particle size has to be broken down in the digestive tract and rarely are these dissolved completely hence they ...

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PDF Preparation of Polypropylene Powder by Dissolution

PDF Preparation of Polypropylene Powder by Dissolution

Jul 14, 2019 Findings The results show that the PP powder has a nearly spherical shape, smooth surfaces, an appropriate average particle size of 63.6 μm, a …

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Particle Size Analyzers FBRM and PVM Instruments

Particle Size Analyzers FBRM and PVM Instruments

A particle size analyzer is an analytical instrument that measures, visualizes and reports a particle size distribution for a given particle or droplet population. Particle size analyzers play an important role during process development and quality control of particle systems in order to develop efficient processes and achieve high final product quality.

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Methods of particle size measrement 032

Methods of particle size measrement 032

Methods of particle size measrement (032) 1. 05-11-2013 Name: Hafiz Luqman Khalil (032) Place Photo Here, Otherwise Delete Box 5th Semester, Chemical Engineering Topic: Methods of Particle Size Measurement Particle Technology Submitted to: Engr. Mohammad Waqas Qamar 06-11-2013 2.

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